Effect of Pretreatment With Extract of Origanum vulgare Leaves on Experimental Intestinal Ischemia-Reperfusion Injury in Rats
نویسندگان
چکیده
Background: Origanum vulgare is used in traditional medicine for antimicrobial, anti-inflammatory and antioxidant activities. Objectives: The present study was designed to investigate the protective effects of O. vulgare leaves extract on experimentally induced intestinal ischemia/reperfusion (I/R) injury in rats. Materials and Methods: In this experimental study, 24 male Wistar albino rats randomly divided into four groups. Group I/R underwent ischemia-reperfusion of the intestine (45 minutes of ischemia followed by 1 hour of reperfusion). Treatment groups I and II were givenO. vulgare extract (200 and 400 ppm) via oral gavages for 1 week before inducing I/R. Group sham was given normal saline orally without inducing I/R. After the experiments, the jejunum was removed and the tissues were processed for histomorphometric examination of mucosa. Results: The treatment withO. vulgareextract significantly decreased mucosal damages in the treatment groups compared to group I/R, while severe mucosal damages were observed in the group I/R. Also, there was significant difference between treatment groups I and II (P = 0.054). Group sham observed normal intestinal mucosa. Conclusions: According to the results of current study, administration of O. vulgare extract protects the intestinal mucosa from I/R
منابع مشابه
The Protective Effect of Orally Administered Amlodipine against Intestinal Ischemia-Reperfusion Injury in Rats
Objective- This study investigated the effect of amlodipine on intestinal ischemia-reperfusion injury in ratsDesign-Experimental studyAnimals-Fifteen male Sprague-Dawly rats weighing 200-220gProcedure- Rats were randomly divided into 3 groups: IR group (operation with clamping), sham group (operation without clamping), and IRA group (operation with clamping and 5mg/kg amlodipi...
متن کاملProtective Effect of Trigonella foenum graecum (fenugreek) Seed Extract on Experimental Intestinal Ischemia/Reperfusion Injury in Rats
Objective- This study was performed to evaluate whether Trigonella foenum graecum (fenugreek) seeds extract has any protective activity in intestinal ischemia/reperfusion injury in rat. Design- Experimental study. Animals- 20 male Wistar albino rats. Procedures- Four groups of rats were included in this study. Group I (I/R) underwent ischemia-reperfusion (I/R) of the intestine (45 min of isc...
متن کاملProtective Effect of Crataegus Hydroalcoholic Extract on Intestinal Ischemia-Reperfusion Injury in a Rat Model
Objective- This study examined the effect of Crataegus hydroalcoholic extract (CHE) on intestinal ischemia-reperfusion (I/R) in rats. Design- Experimental study Animals- 25 adult male Wistar rats Procedures- Rats weighing 200±25 g were randomly divided into five individual groups as follows: sham group without...
متن کاملValuation of Origanum vulgare (leaves, stems and flowers) extract on spatial learning in male rats
Introduction: Origanum vulgare a rich source of natural phenolic antioxidants and has potential to be a source nutritional ingredients for functional food. Herbs such as Origanum have long been used in food preservation d in traditional medicine in the treatment of common ailments and have potential for positive modulation oxidation-linked diseases such as diabetes. Here we investigated t...
متن کاملThe preventive effects of dexmedetomidine against intestinal ischemia-reperfusion injury in Wistar rats
Objective(s): Intestinal ischemia-reperfusion is a major problem, which may lead to multiorgan failure and death. The aim of this study was to evaluate the protective effects of dexmedetomidine on cell proliferation, antioxidant system, cell death, and structural integrity in intestinal injury induced by ischemia-reperfusion in rats. Materials and Methods: Animals were randomized into three gro...
متن کامل